Src antibody

Catalog No. ABIN387822

This anti-Src antibody is a Mouse Monoclonal antibody detecting Src in WB and IF. Suitable for Human and Mouse. This Primary Antibody has been cited in 3+ publications.

Quick Overview for Src antibody (ABIN387822)

Target: Src (Proto-oncogene tyrosine-protein kinase Src (Src))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This Src antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: 17AT28

Product Details anti-Src Antibody

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This Src antibody is generated from mouse immunized with a recombinant protein of full length human SRC.

Isotype: IgG1

Application Details

Application Notes: IF: 1:10~50. WB: 1:500. WB: 1:2000. WB: 1:100~500. WB: 1:100~500. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-Src antibody (ABIN387822)

Nicholson, Seta, Lee, Morgan: "MicroRNA-203 mimics age-related aortic smooth muscle dysfunction of cytoskeletal pathways." in: Journal of cellular and molecular medicine, Vol. 21, Issue 1, pp. 81-95, (2017) (PubMed).

Marcotte, Smith, Sanguin-Gendreau, McDonough, Muller: "Mammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 8, pp. 2808-13, (2012) (PubMed).

Chen, Li, Zhang, Yi, Chen, Wang, Zhang: "Src-stimulated IRTKS phosphorylation enhances cell migration." in: FEBS letters, Vol. 585, Issue 19, pp. 2972-8, (2011) (PubMed).

Target Details for Src

Target: Src (Proto-oncogene tyrosine-protein kinase Src (Src))

Alternative Name: Src

Background: This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.

Molecular Weight: 59835

Gene ID: 6714

NCBI Accession: NP_005408, NP_938033

UniProt: P12931

Pathways: JAK-STAT Signaling, Neurotrophin Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization, Regulation of Carbohydrate Metabolic Process, Autophagy, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling, Platelet-derived growth Factor Receptor Signaling, Thromboxane A2 Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling